Cytotoxic Activity of Sponge Extract and Cancer Cell Lines from Selected Sponges  

K. Chairman , A.J.A. Ranjit Singh
Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Manonmaniam Sundaranar University, Alwarkurichi, Tirunelveli, Tamilnadu, India-627 412.
Sri Paramakalyani College, Alwarkurichi, Tirunelveli, Tamilnadu, India - 627 412
Author    Correspondence author
Biomaterial and Biomedicine, 2013, Vol. 2, No. 1   doi: 10.5376/bb.2013.02.0001
Received: 21 Dec., 2012    Accepted: 09 Jan., 2013    Published: 19 Feb., 2013
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Chairman and Ranjit Singh, 2013, Cytotoxic Activity of Sponge Extract and Cancer Cell Lines from Selected Sponges, Biomaterial and Biomedicine, Vol 2, No.1 1-5 (doi: 10.5376/bb.2013.02.0001)


In this study, the ancancer activity exhibited by sponge fraction extracts from Aurora globostellata from Turicorin coasts. Antitumoural activities were determined by a cytotoxic assay with three different tumoural cells lines HeLa (Human cervical cancer), Raw 264.7 (Mouse leukaemic monocyte macrophage cell line) and HEK-293 (Human kidney cell line). Among the species under study, Aurora globostellata, displayed a high anticancer activity. Further to the fractionation of these crude extracts, a significant correlation was found in most fractions between the high anticancer activity and the high phenolic content. Aurora globostellata marine sponge exhibited strong cytotoxic activities against all tumoural cells.

Marine sponge; Phenolic compound; Antitumour activity; MTT assay
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