QBioDiff: a web-based tool for quantification and interpretation of biological dif-ferences among multiple samples  

Liu Hongbo1 , Liu Xiaojuan2 , Shang Shipeng1 , Zhang Yan1
1 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
2 Department of Rehabilitation, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Author    Correspondence author
Cancer Genetics and Epigenetics, 2015, Vol. 3, No. 4   doi: 10.5376/cge.2015.03.0004
Received: 01 May, 2015    Accepted: 21 May, 2015    Published: 04 Jun., 2015
© 2015 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Hongbo Liu., Xiaojuan Liu., Shipeng Shang and Yan Zhang., 2015, QBioDiff: a Web-based Tool for Quantification and Interpretation of Biological Differences Among Multiple Samples, Cancer Genetics and Epigenetics, Vol.3, No.4 1-4


QBioDiff is a web-based tool for quantification and interpretation of biological difference of the regions of interest (ROIs) among multiple samples by adapted Shannon entropy. QBioDiff web server provides quantitative difference analysis tools including difference quantification, differential ROIs identification, result visualization and functional analysis, for the omics data profiled by high-throughput technologies such as microarrays and next-generation sequencing. In particular, standalone software is provided for pretreatment of next-generation sequencing data. The platform-free and species-free nature of QBioDiff makes it applicable to various QBioDiff. This approach is effective for the high-throughput identification of the functional regions involved in various biological progresses. The tools for integrated analysis and result visualization facilitate the interpretation of the biological mechanism hidden in high-throughput data.
Availability and implementation: The web server QBioDiff is available at the web site http://bioinfo.hrbmu.edu.cn/QBioDiff/

QBioDiff; Omics Data; Biological Differences; Regions of Interest
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