Comparative Study of Cellular Tumor Antigen p53 Protein of Fishes and Analysis of its Protein Interaction Network using Computational Approach  

Suchitra Kumari , Kiran D. Rasal , Jitendra K. Sundaray , Samiran Nandi , P. Jayasankar
Fish Genetics and Biotechnology Division,ICAR- Central Institute of Freshwater Aquaculture, Bhubaneswar, Orissa, 751002, India
Author    Correspondence author
Computational Molecular Biology, 2015, Vol. 5, No. 3   doi: 10.5376/cmb.2015.05.0003
Received: 10 Mar., 2015    Accepted: 15 May, 2015    Published: 21 May, 2015
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Kumari et al., 2015, Comparative Study of Cellular Tumor Antigen p53 Protein of Fishes and Analysis of its Protein Interaction Network using Computational Approach, Computational Molecular Biology, Vol.5, No.3, 1-9 (doi: 10.5376/cmb.2015.05.0003)

Abstract

Progress in the field of Bioinformatics has been facilitated to understand the global network of genes and their protein products. In present study, comparative analysis of Cellular tumor antigen p53 proteins of nine fishes were carried out using Bioinformatics tools. Cellular tumor antigen p53 acts as a tumor-suppressor and having role in apoptosis, genomic stability. The results of this study indicate that, most of physico-chemical properties were almost same in Q92143 (Xiphophorus maculates) and O57538 (Xiphophorus helleri). In order to understand global network of Cellular tumor antigen p53, we have used STRING 9.1 tool and speculated that this protein interacting with several other protein but functional node -CHEK1, BCL2, MDM4 were common in Danio rerio, Oryzias latipes, Tetraodon miurus with high confidence score. The strong association interaction has seen between mdm2 and p53 with a good high score in Danio rerio. We also studied the molecular docking between Cellular tumor antigen p53 and Mdm2 of Zebrafish. Also, we have investigated conserved region present in all nine different protein sequences which specifies, that region maintained by evolution despite speciation. The present study will further support to understand the roles and associated proteins in various cellular pathways in fish.This work is also useful for the study of structural and functional analysis of p53 protein.

Keywords
Cellular tumor antigen p53; Sequence analysis; Protein interaction network; Conserved region; Bioinformatics; Physico-chemical properties; Mdm2
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