The Neurospora crassa cmd, trm-9, and nca-2 Genes Play a Role in Growth, Development, and Survival in Stress conditions  

Vijya Laxmi , Ranjan Tamuli
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781 039, India
Author    Correspondence author
Genomics and Applied Biology, 2015, Vol. 6, No. 7   doi: 10.5376/gab.2015.06.0007
Received: 24 Apr., 2015    Accepted: 02 Aug., 2015    Published: 14 Oct., 2015
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Preferred citation for this article:

Laxmi V. and Tamuli R., 2015, The Neurospora crassa cmd, trm-9, and nca-2 Play a Role in Growth, Development, and Survival in Stress conditions, Genomics and Applied Biology, Vol.6, No.7, 1-8 (doi: 10.5376/gab.2015.06.0007)

Abstract

The calmodulin protein antagonists, trifluoperazine (TFP) and chlorpromazine (CPZ) inhibit the growth, carotenoids accumulation and sexual development of Neurospora crassa. In addition, N. crassa strains lacking trm-9, a cation-ATPase, showed defect in growth. Moreover, strains lacking both trm-9 and another Ca2+-ATPase nca-2, exhibited a severe growth defect, an increased sensitivity to CaCl2, and a reduction in acquisition of thermotolerance induced by heat shock temperature. Therefore, the cmd, trm-9, and nca-2 play a role in growth, survival in calcium stress and induced heat shock temperature in N. crassa.

Keywords
Calcium signaling; Ca2+/cation ATPases; Calmodulin; Neurospora crassa; nca-2; thermotolerance
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