Research Article

Metagenome: Differences in the Gut Microbiota among Healthy, Obese and Type 2 Diabetes Adults  

Roseni  Kaliyappan1 , Syafinaz Amin Nordin1 , Barakatun Nisak Mohd  Yusof 2 , Sieo Chin  Chin3 , Gan Han  Ming4
1Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
2Department of Nutrition and Dietetic, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
3Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
4School of Science, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia
Author    Correspondence author
Genomics and Applied Biology, 2016, Vol. 7, No. 3   doi: 10.5376/gab.2016.07.0003
Received: 09 Sep., 2015    Accepted: 31 Oct., 2015    Published: 10 Oct., 2016
© 2016 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Kaliyappan R., Amin-Nordin S., Yusof B.N.M., Chin S.C., and Ming G.H., 2016, Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults, Genomics and Applied Biology, 7(3): 1-10(doi:10.5376/gab.2016.07.0003)

Abstract

The association between gut microbiota composition with pathogenesis of metabolic diseases namely obesity and type 2 diabetes are increasingly recognized. The aim of the study was to identify the diversity of gut microbiota phylum and families in the gut of healthy, obese and type 2 diabetes adults with metagenomic approach. Six healthy subjects, five obese subjects and five type 2 diabetes subjects of similar inclusion and exclusion criteria were recruited. The different bacterial phyla and families in the stool sample were analyzed with metagenomic analysis. The median(IQR)% of relative abundance for each phylum and families were analyzed. The obese subjects had higher Bacteroidetes 63.50(21.55)% with lower Firmicutes 27.00(13.55)%, meanwhile, the type 2 diabetes subjects also had higher Bacteroidetes 66.50(39.00)% with lower Firmicutes 27.70(19.35)%. These findings shows that there are differences in the gut microbiota composition in the healthy, obese and type 2 diabetes adults which may influence the development of obesity and type 2 diabetes.

Keywords
Obese; Type 2 diabetes; Metagenome
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