Research Progress of Marinobufagenin and Salt-Sensitive Hypertension
Zunyi Medical College in Zhuhai campus, Zhuhai, 519000, China
Genomics and Applied Biology, 2018, Vol. 9, No. 1 doi: 10.5376/gab.2018.09.0001
Received: 15 Nov., 2017 Accepted: 05 Dec., 2017 Published: 12 Jan., 2018
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Preferred citation for this article:
Fang X.X., Jing X.H., Wang J.F., and Gao Y., 2018, Research progress of marinobufagenin and salt-sensitive hypertension, Genomics and Applied Biology, 9(1): 1-5 (doi: 10.5376/gab.2018.09.0001)
Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the unitary ligand of Na+/K+ ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention, increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na+/K+ ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.
Marinobufagenin; Salt-sensitive hypertension; Na+/K+-ATPase; Endogenous digitals-like substance
Genomics and Applied Biology
• Volume 9