Trisomy 6 as Sole Cytogenetic Abnormality in Acute Myeloid Leukemia “A Case Series† 

Salil Vaniawala , Avani Kathiriya , Pankaj Gadhia
Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 4   doi: 10.5376/ijccr.2015.05.0004
Received: 25 Nov., 2014    Accepted: 17 Dec., 2014    Published: 30 Jan., 2015
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Preferred citation for this article:

Vaniawala et al., 2015, Trisomy 6 as Sole Cytogenetic Abnormality in Acute Myeloid Leukemia “A Case Series”, International Journal of Clinical Case Reports, Vol.5, No.4 1-3 (doi:  10.5376/ijccr.2015.05.0004)

Abstract

Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias. We report three cases of trisomy 6 as sole cytogenetic abnormality in acute myeloid leukemia (AML). Short-term unstimulated bone marrow culture showed two cases of AML-M1 and one case of AML-M2 with trisomy 6. It is known that trisomy 6 is a rare numerical abnormality and prognostic significance is not well established. More studies are required to assign the role of trisomy 6 in the development of leukemia as well as in prognosis.

Keywords
Bone marrow; G-Banding; Karyotype; AML; Trisomy 6
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