Primary Thyroid Lymphomas: Clinicopathologic Study of 10 Cases and Review of the Literature
Soumeya Nora Fedala1
Ali El Mahdi Haddam2
Radhia Si nora Youcef3
Farida Chentli Djamila Meskine2
1 Department of endocrinology bab el oued hospital, Algeria
2 Department of endocrinology bologhine hospital, Algeria
3 Department of biochemistry bab el oued hospital, Algeria
4 Department of endocrinology Mustapha hospital, Algeria
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 5 doi: 10.5376/ijccr.2015.05.0005
Received: 25 Oct., 2014 Accepted: 17 Nov., 2014 Published: 30 Jan., 2015
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Preferred citation for this article:
Fedala et al., 2015, Primary Thyroid Lymphomas: Clinicopathologic Study of 10 Cases and Review of the Literature, International Journal of Clinical Case Reports, Vol.5, No. 5 1-4 (doi: 10.5376/ijccr.2015.05.0005)
Non-Hodgkin thyroid primitive lymphomas are rare; they account less than 2 to 5% of thyroid cancers. The objective of this study is to report the clinical, therapeutic and evolutionary of ten cases collected in 33 years of thyroid lymphoma features, in which the female sex was exclusive. The median age at diagnosis was 56.5 years and the call signs were in all cases represented by a neck mass associated to a rapid local changing with obstructive symptoms facts of dyspnea and dysphonia.
The histopathological diagnosis with immunostaining after surgery, found in all cases a non-Hodgkin's lymphoma with a predominance of large cell form. The coexisting of Lymphocytic Hashimoto's thyroiditis with primary malignant thyroid lymphoma was found in 20% of cases.
Concerning the treatment of lymphoma, all patients were operated because of compressive character of goiter. Three patients were treated with chemotherapy alone and five by combining chemotherapy and radiotherapy treatment. Two women were unfortunately died before any treatment. The evolution was marked by the deaths of two patients two months after chemotherapy. No tumor recurrence was observed in the other patients (60%) after a mean follow-up of four years .The prognosis of localized stages is generally favorable.
Non Hodgkin lymphoma; Thyroidectomy; Prognosis, Hashimoto thyroiditis; Immune histochimichemestry; Retrospec¬tive study