Peripheral Giant Cell Granuloma: Recurrence, A Persisting Problem  

Kaustubh P. Patil1 , Ketki P. Kalele2 , Vinayak D. Kanakdande3 , Abhishek Singh Nayyar4
1. Department of Periodontics and Oral Implantology, Dr. D.Y. Patil Dental College & Hospital, Pune, Maharashtra, India
2. Department of Oral and Maxillofacial Pathology and Microbiology, V.Y.W.S Dental College & Hospital, Amravati, Maharashtra, India
3. Department of Periodontics and Oral Implantology, Nanded Rural Dental College and Research Centre, Nanded, Maharashtra, India
4. Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College& Hospital& Post-Graduate Research Institute, Parbhani, Maharashtra, India
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 22   doi: 10.5376/ijccr.2015.05.0022
Received: 10 Apr., 2015    Accepted: 25 May, 2015    Published: 09 Jun., 2015
© 2015 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Patil et al., 2015, Peripheral Giant Cell Granuloma: Recurrence, A Persisting Problem, International Journal of Clinical Case Reports, Vol.5, No.22 1-6 (doi: 10.5376/ijccr.2015.05.0022)


Peripheral Giant Cell Granuloma is a non-neoplastic, tumor-like, reactive lesion occurring exclusively on gingiva/alveolar crest. It is thought to arise from the periodontal ligament or periosteum. Clinically, it bears resemblance to pyogenic granuloma, peripheral ossifying fibroma and many other peripheral soft tissue lesions seen in the oral cavity, thereby making histopathology mandatory for the diagnosis of this lesion. The lesion although being relatively common still carries a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells as well as its treatment. The entity further holds significance because of its notorious behavior and its high tendency to recur. The present paper describes a case report on recurrent peripheral giant cell granuloma with a comprehensive insight of the literature on its clinical and histological aspects. Special attention has been given on the histogenesis of its cells and treatment of this lesion.

Abbreviations Peripheral Giant Cell Granuloma (PGCG), Central Giant Cell Granuloma (CGCG), Peripheral Ossifying Fibroma (POF).

Peripheral Giant Cell Granuloma; Giant Cell Lesion; Multinucleated Giant Cells; Mononuclear Stromal Cells; Myeloid Tumor; Osteoclasts
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