Pediatric Craniopharyngioma  

Azzoug S. , Belhadj Aissa N. , Chentli F.
Endocrine and Metabolic diseases Department Bab El Oued Hospital Algiers, Algeria
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 48   doi: 10.5376/ijccr.2015.05.0048
Received: 20 Jul., 2015    Accepted: 22 Aug., 2015    Published: 08 Dec., 2015
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Azzoug S., Belhadj Aissa N., Chentli F., 2015, Pediatric Craniopharyngioma, International Journal of Clinical Case Reports, 5(48) 1-2 (doi: 10.5376/ijccr.2015.05.0048)

Abstract

Craniopharyngioma are epithelial tumors of the sellar and suprasellar region derived from Rathke cleft. They are among the most common forms of cerebral tumors in children. Although they are histologically benign they may have severe complications due to their proximity to vital structures. Furthermore they often recur after surgical resection. The aim of our study was to analyze the clinical profile, radiological aspect and complications of pediatric craniopharyngioma. The medical records of 47 patients (28M/19F) harboring a craniopharyngioma were reviewed. Mean age at diagnosis was 11.2 ± 5.4 years. Mean size of the tumor was 37 ± 10.7 mm. Appealing symptoms were ophthalmological complaints in 34.6%, neurological signs mainly headaches in 28.2%, intracranial hypertension in 28.2%, endocrine symptoms in 9%. Endocrine repercussions were anterior pituitary deficiency in 72.4% (global in 32% and partial in 40.4%) and diabetes insipidus in 46.8%. 68% of patients have visual acuity impairment among which 21.2% were blind (12.7% bilateral and 8.5% unilateral blindness). 12.7% of patients have ocular motor palsy. All patients were operated on sometimes more than once; radiotherapy was used in 20.5%. Craniopharyngioma are rare tumors which may have severe endocrine, neurological and visual repercussions; it often needs iterative surgery sometimes combined with radiotherapy.

Keywords
Pediatric craniopharyngioma; Visual impairment; Endocrine dysfunction
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