Familial Pyoderma Gangrenosum: About 2 cases  

Nabil  Bel Feki , Monia  Smiti-Khanfir , Fatma  Said , Imed  Ben Ghorbel , Thouraya  Ben Salem , Mounir  Lamloum , Amira  Hamzaoui , Mohamed  Habib Houman
Department of Internal Medicine, University Hospital of La Rabta, Tunis, Tunisia
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 50   doi: 10.5376/ijccr.2015.05.0050
Received: 21 Jul., 2015    Accepted: 22 Aug., 2015    Published: 11 Dec., 2015
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Preferred citation for this article:

Nabil Bel Feki, Monia Smiti-Khanfir, Fatma Said, Imed Ben Ghorbel, Thouraya Ben Salem, Mounir Lamloum, Amira Hamzaoui, and Mohamed Habib Houman, 2015, Familial Pyoderma Gangrenosum: About 2 cases, International Journal of Clinical Case Reports, 5(50): 1-3 (doi: 10.5376/ijccr.2015.05.0050)

Abstract

Pyoderma gangrenosum occurrence in a familial pattern is extremely rare. We report pyoderma gangrenosum in two Tunisian siblings with onset respectively at 28 and 26 years old. The initial lesion was a pustule that breaks down to form an ulcer with an erythematous border. Treatment with oral corticosteroids induced an excellent clinical response. This familial clustering suggests a possible genetic role in the development of pyoderma gangrenosum in some cases.

Keywords
Pyoderma gangrenosum; Heredity; corticosteroids
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