The Cowden Syndrome: A Case Report  

Mohammed El Amine AMANI
Department of Endocrinology and Diabetology 1ST November Hospital Oran, Algeria
Author    Correspondence author
International Journal of Clinical Case Reports, 2016, Vol. 6, No. 12   doi: 10.5376/ijccr.2016.06.0012
Received: 22 Feb., 2016    Accepted: 28 Mar., 2016    Published: 05 May, 2016
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Preferred citation for this article:

Mohammed El Amine Amani, and Souad Miraoui, 2016, The Cowden Syndrome: A Case Report, International Journal of Clinical Case Report, 6(12): 1-3 (doi: 10.5376/ijccr.2016.06.0012)


We report on a 42-year-old woman who presented a mild mental retardation, a dolichocephaly, multiple papules scattered throughout the body, two scars cervicotomy with a stage II heterogeneous goiter with a discrete hypothyroidism. The Cowden syndrome has been suspected by the dermatologist. Histopathological examination of the thyroid nodule was in favor of a micro-invasive carcinoma. The mammography showed multiple breast nodules, ACR2 class with a malignant histology. The esophagogastroduodenoscopy showed small gastric and duodenal polyps pinhead and the nasofibroscopy revealed nasopharyngeal polyps with decreased mobility of the vocal cords. The genetic study could not be performed. It seems essential to insist that the dermatologist must suspect the Cowden syndrome in all patients with mucocutaneous lesions. Weakened by her divorce, unsightly look, the heavy monitoring and the vital risk require psychological support as there is currently no specific treatment.

Cowden syndrome; Thyroid carcinoma; Breast cancer; Gastrointestinal polyps
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