Factors Associated With Atherosclerosis Expansion in Patients with Coronary Artery Disease
Larisa N. Yakovleva
Olga E. Matuzok
Igor V. Kuznetsov
Vira I. Tseluyko
Kharkiv Medical Academy of Postgraduate Education, Ukraine
International Journal of Molecular Medical Science, 2014, Vol. 4, No. 3 doi: 10.5376/ijmms.2014.04.0003
Received: 08 Apr., 2014 Accepted: 10 May, 2014 Published: 17 Jun., 2014
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Aim of this study was investigation of possible relations of traditional risk factors and polymorphism of endothelial NO synthase (еNOs) gene, angiotensin-converting enzyme (ACE) gene and gene of type 1 angiotensin II receptors (АT2R1) with atherosclerosis expansion in patients with coronary artery disease.
We examined 120 patients with CAD (108 male, 12 female) with stable angina pectoris of ІІ–ІІІ functional class and haemodynamically significant coronary artery stenosis confirmed by coronary angiography. Examination included: usual clinical tests; ankle-brachial pressure index measurement; doppler-ultrasound of lower limb vessels and carotid arteries with quantitative evaluation of intima-media thickness; exercise tolerance testing. Patients were divided into 2 groups: group 1 - 55 patients with signs of atherosclerosis in 2 or more vascular areas, group 2 - 65 patients with isolated coronary atherosclerosis.
Allele polymorphism of Т-786С promotor of еNOs gene, I/D polymorphism of ACE gene and А1166С polymorphism of АT2R1 gene were determined in polymerase chain reaction. We used Student’s t -Test to compare quantitative signs and Pearson Х2 criterion to compare qualitative ones, multifactorial step-by-step regression analysis to reveal cause-and-effect relations.
Signs of non-coronary atherosclerosis were found in 48.5% of our patients. Patients with CAD and multiple locus atherosclerosis were more likely to have mutant alleles of Т-786С polymorphism of еNOs gene and А1166С polymorphism of АT2R1 gene. We found an independent relation between multiple locus atherosclerosis and smoking, type II diabetes mellitus, family history of cardiovascular diseases with early onset, multivessel CAD and presence of С allele of Т-786С polymorphism of еNOs gene.
Atherosclerosis; Risk factors; Gene polymorphism; Coronary artery disease