The Activities of Vitamin D and Anti-Thyroperoxidase (Anti-TPO) Antibodies in Uncontrolled Type 2 Diabetes  

Sabitha Kandi1 , Md Rafi1 , B. Venugopal1 , G. Rajkumar , K.V. Ramana2
1. Department of Biochemistry, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
2. Department of Microbiology, Prathima Institute of Medical sciences, Karimnagar, Telangana, India
Author    Correspondence author
International Journal of Molecular Medical Science, 2015, Vol. 5, No. 1   doi: 10.5376/ijmms.2015.05.0001
Received: 31 Jan., 2015    Accepted: 28 Feb., 2015    Published: 03 Mar., 2015
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Kandi et al., 2015, The Activities of Vitamin D and Anti-Thyroperoxidase (Anti-TPO) Antibodies in Uncontrolled Type 2 Diabetes, International Journal of Molecular Medical Science, Vol.5, No.1, 1-3 (doi: 10.5376/ijmms.2015.05.0001)


The fat soluble vitamin D, anti Thyroperoxidase (anti TPO) enzyme, an enzyme involved in thyroid hormone synthesis has a role in uncontrolled type 2 diabetes mellitus (T2D). Vitamin D has diverse functions in human body and it carries out its function via vitamin D receptors (VDR). This VDRs are present in most types of immune cells. The immuno modulator property of vitamin D is due to its effects on T and B lymphocytes. Thus, vitamins D modifies cell mediated immune responses and regulate inflammatory T cell activity.  In T2D,  there is insulin resistance (high titers of insulin antibodies), decreased vitamin D activity and increased anti TPO levels. This study concludes a probable relation between immune related activity, signaling molecules in T2D which increases the progression of this condition to autoimmune thyroid disease.

Vitamin D; Anti TPO antibodies; Type 2 diabetes; Insulin resistance
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