Serum Advanced Oxidation Protein Products (AOPP) in Oral Squamous Cell Carcinoma (OSCC): Possible Markers of Diagnostic Significance  

Abhishek Singh Nayyar
Assistant Professor, Department of Oral Medicine & Radiology, H.No.44, Behind Singla Nursing Home, New Friends’colony, Model Town, Panipat-132103, Haryana, India
Author    Correspondence author
International Journal of Molecular Medical Science, 2013, Vol. 3, No. 5   doi: 10.5376/ijmms.2013.03.0005
Received: 27 Mar., 2013    Accepted: 11 Apr., 2013    Published: 17 Jun., 2013
© 2013 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Objectives: The aim of this study was to measure the concentrations/levels of serum total proteins and advanced oxidation protein products as the markers of oxidant mediated protein damage in the sera of patients with oral cancers.
Methodology: The study consisted of the sera analysis of serum total protein, albumin and advanced oxidation protein products' levels in 30, age and sex matched controls, 60 patients with reported pre-cancerous lesions and/or, conditions and 60 patients with histologically proven oral squamous cell carcinoma. One way analyses of variance were used to test the difference between groups. To find out which of the two groups' means are significantly different, post-hoc test of Bonferronitest was used. The results were averaged as mean +/- standard deviation. In above test, P values less than 0.05 were taken to be statistically significant. The normality of data was checked before the statistical analysis was performed.
Results: The study revealed variations in serum levels of advanced oxidation protein products to be statistically significant (p<0.001). Serum levels of total protein showed extensive variations in the study and the results were largely inconclusive and statistically insignificant.
Conclusion: The results obtained emphasize the need for more studies with larger sample sizes to be conducted before a conclusive role could be drawn in favor of sera levels of total protein and advanced oxidation protein products as markers of diagnostic significance and of the transition from the various oral pre-cancerous lesions and conditions into frank oral cancers.

Keywords
Oral squamous cell carcinoma; Reactive oxygen species; Free radicals; Transformation; Pre-cancerous; Serum albumin
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