Research Article

Histopathological Evaluation of Infected Wistar Albino Rat Treated with Phyllanthus niruri L.  

Osho I.B.1 , Oyekanmi B.A.2 , Adetuyi F.C.3 , Oladele A.A.4
1 Department of Animal Production and Health, School of Agriculture and Agricultural Technology, Federal University of Technology, Akure, Nigeria
2 Department of Haematology, College of Health Sciences, Osun State University, Osun State, Nigeria
3 Department of Microbiology, School of sciences, Federal University of Technology, Akure, Nigeria
4 Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex, Osun State, Nigeria
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2015, Vol. 5, No. 3   doi: 10.5376/ijmvr.2015.05.0003
Received: 09 Dec., 2015    Accepted: 03 Feb., 2016    Published: 20 Mar., 2016
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Preferred citation for this article:

Osho I.B., Oyekanmi B.A., Adetuyi F.C. and Oladele A.A., 2016, HISTOPATHOLOGICAL EVALUATION OF INFECTED WISTAR ALBINO RAT TREATED WITH Phyllanthus niruri L, International Journal of Molecular Veterinary Research, Vol.5, No.03 1-8 (doi: 10.5376/ijmvr.2015.06.0004)


Phyllanthus had been reported to have pharmacological effects such as antibacterial, antiviral activity against hepatitis. P. amarus has been used as chemoprotective agent and antimutagenic. Several active components have been identified in Phyllanthus, some of which are phyllantin, flavonoid, alkaloids, tannins, terpens, and sterols. Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. Due to the worldwide usage of Phyllanthus, this study focuses on the toxicology effect of the species in our environment in order to assess the biosafety of the plant. 


Apparently healthy Wistar albino rats were given 0.3 ml oral administration of Escherichia coli (ATCC 2522) of standard inoculum. The infected animals experienced reduction in the average body weight gain after three days inoculation, which increased drastically after a week and two weeks treatment, for positive and test animals respectively. At the end of the treatment, negative control and positive control have 6.37% and 15.21% average body weight gain respectively. In the test animals the least percentage weight gain was 10.83% (1200 mg/kgbw) and the highest percentage weight gain was 26.22% (300 mg/kgbw). The hyperchromasia of the liver tissue and vacuolations of the podocytes is suggestive of potential toxic properties of P. niruri L. in chronic administration.

Phyllanthus niruri; In vivo; Chemoprotective; Antibacterial; Histopathology
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International Journal of Molecular Veterinary Research
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