Clinical Efficacy of Allopurinol and Ketoprofen in the Treatment of Urate Associated Urolithiasis in Bucks- Case Report  

Ali Raza1 , Ghulam Muhammad1 , Asad Manzoor1 , Mansoor Ahmad2 , Misbah Ijaz1
1. Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan
2. Department of Parasitology, Faculty of Agriculture, Faisalabad, Pakistan
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2012, Vol. 2, No. 6   doi: 10.5376/ijmvr.2012.02.0006
Received: 03 Dec., 2012    Accepted: 23 Dec., 2012    Published: 28 Dec., 2012
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Ali Raza et al., 2012, Clinical Efficacy of Allopurinol and Ketoprofen in the Treatment of Urate Associated Urolithiasis in Bucks – Case Report, International Journal of Molecular Veterinary Research, Vol.2, No.6 22-24 (doi: 10.5376/ijmvr.2012.02.0006)

Abstract

Urolithiasis, the leading cause of urine retention in male goats is a painful, stressful and even life threatening condition. The most common sites of urolithiasis in male sheep and goat are sigmoid flexure and urethral process. Owing to specialized structures, the lodging of calculi at these anatomical sites presents several pitfalls in their surgical correction. The nature of the calculi is generally a function of the diet and pH of the urine. Alkaline pH (pH>8.0) of the urine favors the formation of phosphate, carbonate and struvite calculi while acidic urine (pH<7.0) predisposes the animal to urate and silicate calculi. Urate calculi are found rarely in the urine of goats. The present report describes 2 clinical cases of urate associated urolithiasis in bucks that was diagnosed on the basis of history, physical examination and urine analysis. The bucks were treated with allopurinol @ 10 mg/kg of body weight PO, bid along with ketoprofen @ 3 mg/kg body weight IM sid for 3 days. Both the bucks recovered completely with 3 days treatment.

Keywords
Sheep and Goat; Urine retention; Urate associated urolithiasis; Allopurinol; Ketoprofen
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