Pharmacology and Clinical Use of Dimethyl Sulfoxide (DMSO): A Review
Krishi Vigyan Kendra, Aland road, Gulbarga, UAS, Raichur, Karnataka, India-585 101
International Journal of Molecular Veterinary Research, 2013, Vol. 3, No. 6 doi: 10.5376/ijmvr.2013.03.0006
Received: 27 Mar., 2013 Accepted: 11 Apr., 2013 Published: 20 Aug., 2013
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Preferred citation for this article:
Manjunath and Shivaprakash, 2013, Pharmacology and Clinical Use of Dimethyl Sulfoxide (DMSO): A Review, International Journal of Molecular Veterinary Research, Vol.3, No.6 23-33 (doi: 10.5376/ ijmvr.2013.03.0006)
Dimethyl sulfoxide is having a pyramidal structure, CH3-SO-CH3. It is a dipolar, aprotic and highly hygroscopic solvent. It readily penetrates the skin within 5 minutes after cutaneous application. It enhances penetration of Anaesthetic, cardioactive, anticholinesterase and other not-innocuous therapeutic agents. It is recommended for acute sprains, strains, bursitis and their associated soft tissue swellings and haematoma. Combination therapy of DMSO with antibiotics or steroids enhance the healing of cutaneous habronemiasis or summer sores, bumble foot, acral lick dermatitis ,arthritis, and mastitis. It is considered to have a low toxicity. Chronic thermal, chemical exposure of DMSO solvent and higher levels of chemical contaminants with severe electrical burns causes the invasive squamous cell carcinoma of the upper extremities in human beings. The therapeutic intravenous dose is about 1.0 g/kg in 10~45% solution administered slowly in humans, cats, dogs and horses. Intra articular administration of DMSO reduced severity of chemically induced synovitis in horses.
Pharmacology; Dimethyl sulfoxide (DMSO); Radioscavenging property; Therapeutic applications