Engineering B Cells to Express Pathogen-specific Antibodies to Protect Against Infection
Published:22 Oct.2019    Source:Medicalxpress

In a recent study, Howell F. Moffett and an interdisciplinary research team in the departments of Global Health, Immunology, Vaccine and Infectious Disease in the U.S. engineered both human and murine (mouse) B cells in the lab. They engineered the cells to express antibodies that targeted a number of viruses including the respiratory syncytial virus (RSV). The scientists showed that a single injection of B cell expressing RSV-specific antibodies into mice lacking T and B cells to be protective. This new technology, now published in Science Immunology, will open the possibility of using engineered B cells as therapeutics in healthcare.