Gene Drives Likely to Be Foiled by Rapid Rise of Resistance
Published:27 Jul.2017    Source:Science Daily

A study in fruit flies suggests that existing approaches to gene drives using CRISPR/Cas9, which aim to spread new genes within a natural population, will be derailed by the development of mutations that give resistance to the drive.

 

Newly developed approaches that use CRISPR/Cas9 gene editing technology can generate offspring that carry copies of the altered gene on both chromosomes -- a phenomenon called super-Mendelian inheritance that, in theory, should quickly convert an entire population. This process, however, can also create resistant genetic sequences and organisms that cannot be converted.

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