Research Report

Adulticidal Activity of Dillapiol and Semi-synthetic Derivatives of Dillapiol against Aedes aegypti (L.) (Culicidae)  

Ana Cristina Silva Pinto1 , Karla Lagos Nogueira1 , Francisco Celio Maia Chaves2 , Luis Vilmar Souza da Silva3 , Wanderli Pedro Tadei1 , Adrian Martin Pohlit4
1. Laboratory of Malaria and Dengue, Department of Society, Environment and Health, National Institute of Amazonian Research (INPA), Brazil
2. Embrapa Western Amazon; Vegetable and Medicinal Plant, Production Systems, AM Route 010, Km 29, 69010-970, Manaus, AM, Brazil
3. Laboratory of Water Resources, Department of Environmental Dynamics, INPA, Brazil
4. Laboratory of Active Principles of the Amazon (LAPAAM), Department of Technology and Innovation, INPA, Avenida Andre Araujo, 2936, 69060-001, Manaus, AM, Brazil
Author    Correspondence author
Journal of Mosquito Research, 2012, Vol. 2, No. 1   doi: 10.5376/jmr.2012.01.0001
Received: 15 Jun., 2012    Accepted: 04 Jul., 2012    Published: 28 Aug., 2012
© 2012 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Pinto et al., 2012, Adulticidal Activity of Dillapiol and Semi-synthetic Derivatives of Dillapiol against Aedes aegypti (L.) (Culicidae), Journal of Mosquito Research, Vol.2, No.1 1-7 (doi: 10.5376/jmr.2012.01.0001)

Abstract

Phenylpropanoid dillapiol (1) isolated from the essential oil in leaves of Piper aduncum L. and thirteen semi-synthetic, C3 side-chain modified dillapiol derivatives 2-14 were evaluated for lethality against hemorrhagic dengue fever mosquito vector Aedes aegypti L.. First, adult female mosquitoes were exposed to these substances in a contact bioassay carried out in glass bottles at a single surface density (0.57 µg/cm2). Then, median lethal concentrations (LC50) and LC90 were determined for active compounds. It was found that the structure of the C3 side chain was important for the toxic effects of these substances against A. aegypti adult females. Isodillapiol (2) and methyl, propyl and butyl 1-(2´,3´-dimethoxy-4´,5´-methylenedioxyphenyl)propan-2-yl ethers (3, 5 and 6, respectively) all exhibited greater mosquitocidal activity than dillapiol (1). The order of molar per surface area of mosquitocidal activities was isodillapiol (2) > butyl ether 6 > methyl ether 3 > propyl ether 5 > dillapiol (1). The potential of dillapiol and derivatives as A. aegypti mosquitocides was discussed.

Keywords
Mosquitocidal activity; Aedes aegypti; Isodillapiol; 2-methoxy dillapiol; 2-ethoxy dillapiol; 2-n-propoxy dillapiol; 2-n-butoxy dillapiol
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