An Outer Membrane Vesicle Vaccine against Meningococcal Disease in Guangxi Province  

Qingxu Huang , Junyu Lu
Yulin Normal University, Biology Department, Yulin, 537000, P.R. China
Author    Correspondence author
Journal of Vaccine Research, 2014, Vol. 4, No. 1   
Received: 10 Jun., 2014    Accepted: 12 Aug., 2014    Published: 19 Nov., 2014
© 2014 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

An outer membrane vesicle vaccine against acute, systemic disease caused by meningococci of serogroup B has been developed. The vaccine has been tested consecutively in phase I and phase II clinical trials including more than 3 000 volunteers. These trials provided data on safety, immunogenicity and reactogenicity and possible effect on carriage of meningococci in the throat, and consequently formed the basis for two major protection trials; one in secondary school students and one among military recruits. The aims, design and major results of phase I and phase II studies are described as well as the design and organization of the protection trials.

Keywords
Outer membrane vesicle vaccine; Meningococcal disease; Guangxi Province

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