Scientists are actively considering the factors that cause autoimmune disorders. They want to understand the immune responses involved.
So far, they have figured that there is PTPN22 which regulates T-cell response. However, the R620W mutation prevents this response from reaching a point where it can interact with other proteins. To investigate the impact of this, researchers have introduced a variant into mice. They have observed increased T-cell activation. Interestingly, T cells carrying the R620W variant in humans displayed the opposite response.
In a recent study, researchers shed light on these conflicting results. They…
